Burn Therapy and Research

enzyme activities in several inborn errors of metabolism, and regulation of enzyme activity by substrates. It is the only major, large compendium of this breadth of data about the urea cycle enzymes. It contains much original experimental data. The discussions at the end of each presentation illuminate some of the important controversies from mechanisms substrate regulation to clinical investigation and therapy of inborn errors of urea cycle function. This book will be useful to basic scientists interested in regulation of urea cycle enzymes and to clinicians and clinical investigators dealing with patients with the hyperammonemia syndromes, particularly those resulting from urea cycle enzymopathies. MARGRETTA R. SEASHORE Departments of Human Genetics and Pediatrics Yale University School of Medicine